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Glossary / Clinical protocol

Clinical protocol

Definition

A clinical protocol is the written, clinician-approved set of rules a telehealth program follows for a treatment — who is eligible, what must be screened, how the medication is started and adjusted, when follow-up happens, and what triggers escalation — so that care is consistent across every clinician and every patient.

By Lithos Staff · Updated September 2026

At a glance
  • Clinician-approved rules for one treatment
  • Eligibility, screening, titration, follow-up, escalation
  • The floor for care, not a substitute for judgment
  • Encodable as intake schemas and eligibility checks

What a protocol contains

Protocols turn a medical group’s judgment into something a platform can enforce and a clinician can apply quickly.

  • Inclusion and exclusion criteria, including contraindications and interacting medications
  • Required intake elements and any labs or vitals needed before starting
  • Starting dose, titration schedule, and the check-in required before each step
  • Follow-up cadence and re-evaluation intervals, including state-specific ones
  • Red flags that escalate immediately, and to whom

Protocols versus clinician judgment

A protocol is the floor, not the ceiling. It guarantees the minimum that must be checked and the standard path; the clinician still evaluates the individual patient and may deviate with documented reasons. Programs that treat protocols as scripts for rubber-stamping are the ones boards act on; programs that treat them as shared standards are the ones that scale safely.

Protocols in software

Much of a protocol can be encoded: intake schemas that collect the required elements, validation that rejects incomplete cases, eligibility checks that route ineligible requests to a live visit or decline, and titration rules that require a check-in before a dose step. The clinician sees a case that has already been checked against the protocol and spends their time on the decision.

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Lithos runs the clinicians, pharmacies, and 50-state rules behind your care program — one API.

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Frequently asked questions

Who writes clinical protocols for a telehealth program?

The medical group’s clinical leadership — typically a medical director with specialty input — reviewed against current guidelines and state rules. Brands do not write protocols; they choose which protocol-backed treatments to offer.

How often should protocols be updated?

On a schedule (annually is common) and whenever a rule, label, or guideline changes. Each version should be dated so any encounter can be read against the protocol in force at the time.

What is the difference between a protocol and a treatment catalog?

The protocol is the clinical rulebook for a treatment; the catalog is the list of requestable treatments, each pointing at its protocol. The catalog is what products and agents see; the protocol is what clinicians apply.

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